Home > Aptamer Therapeutics > About Aptamer Therapeutics

RIBOMIC, Inc. is a leading company in the world developing innovative aptamer therapeutics.

About Aptamer Therapeutics

アプタマー医薬についてA nucleic acid RNA is a copy of the sequence of the gene information contained in DNA and functions as a mold in composing the proteins in a living body. But in addition to being a copy of the gene information, RNA has an important role in “forming various three dimensional structures.” Aptamer pharmaceutical uses this role of RNA to form RNA molecules (aptamers) that bind with the target protein to inhibit or control the protein’s work. Developed thus for pharmaceutical use is the aptamer drug.

   An important feature of aptamers is shown in the diagram on the right. It is the “shape capturing” which forms the three dimensional structure that fits with the shape of the target protein and controls its activity. An antibody pharmaceutical recognizes six to ten amino acid sequences among the amino acids that form the protein and binds with the target protein. The way that an aptamer captures the target protein is substantially different.